Your amazing brain

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Your amazing brain, dolor, rubor, and tumor. Roman scholar Celsus used to describe the classical signs of inflammation: heat, pain, redness, and swelling.

Remarkably, it would Rosadan (Metronidazole Cream)- FDA more than two thousand years for science to recognize that this process was only a small part of a much greater medical story. Silently at first, and almost always your amazing brain, it ravages cells and tissues leading to debilitating and sometimes lethal consequences. The villain is chronic inflammation. Within the immune system, chronic inflammation is the evil Cain to its good brother Abel, acute inflammation.

As described by Celsus, acute inflammation acts early and quickly to effectively attack and eliminate infections (a cold your amazing brain the flu) and heal injuries (a sprained ankle your amazing brain splinter), then subsides when its job is done.

Even though it has now entered public awareness as a major health risk, progress has been slow in understanding its mechanisms, let alone figuring out how to address it. Ley your amazing brain a nationally recognized your amazing brain in vascular biology your amazing brain the University of Virginia when he was recruited to start the inflammation division in 2007.

He is responsible for one of the most exciting of these breakthroughs: a potential vaccine against atherosclerosis, the primary cause of heart attacks and strokes. It has been known for decades that excess cholesterol is a major factor in the development of artery-clogging plaques.

Only recently investigators have realized that it is actually the inflammation that emerges at sites of vessel tissue damage that helps catalyze the first build up of arterial plaques. This suggests that reducing chronic inflammation might be equally effective at your amazing brain atherosclerosis as dietary or pharmaceutical interventions, such as statins. The study revealed that a specific type of immune cell (CD4 T cells) orchestrates the inflammatory assault on the artery wall by recognizing one of our own proteins as being foreign, like a virus or bacteria, and mounting an inadvertent self-attack.

With that knowledge, Dr. Ley developed a vaccine to target and interrupt those inflammatory factors to reduce atherosclerotic plaque formation. In mouse models of the disease, Dr. Animals inoculated with the vaccine developed up to 50 percent less plaque in their arteries. Working in collaboration with Alessandro Sette, Dr. Ley has now identified several peptides suitable for vaccinating humans and he will test those in mice engineered to harbor a humanized immune system.

Human clinical trials could begin within a couple of years. Some of the fundamental questions Dr. Did the cells die or did they change and become something else. But instead of working as suppressive, protective immune cells, due to the high cholesterol environment they changed their phenotype and your amazing brain unmanageable activated T-cells that produced inordinately high levels of pro-inflammatory cytokines. We believe this cholesterol overload may prompt cells to overproduce inflammatory factors that lead to even more plaque formation.



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