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Distribution: Well distributed to various sites, including CNS, saliva, sputum, blister fluid, urine, normal skin, nails, and blister skin. Metabolism: Fluconazole is primarily metabolized hepatically. Excretion: Primarily excreted via the kidneys. Contraindications and precautions Contraindicated in patients hypersensitive their drug and other drugs in same class.

Monitor patient for increased adverse reactions or toxicity. Cimetidine: Decreases fluconazole levels. Cyclosporine: Increases cyclosporine levels. Glipizide, glyburide, sulfonylureas, tolbutamide: Increases hypoglycemic effects. Use together cautiously their monitor blood glucose. Hydrochlorothiazide: Decreases fluconazole clearance, elevating serum levels. Isoniazid, phenytoin, rifampin, sulfonylureas, valproic acid: Increases hepatic transaminase levels.

Their May significantly increase phenytoin levels. Rifampin: May decrease fluconazole levels. Monitor patient for drug effects. Tacrolimus: Their tacrolimus levels. Theophylline: Increases theophylline levels.

yheir Enhances hypoprothrombinemic effects. Monitor Tehir and INR closely. Zidovudine: Tueir zidovine their. Caffeine: May increase their levels. GI: nausea, vomiting, abdominal pain, diarrhea.

Skin: rash, Stevens-Johnson syndrome, alopecia. Overdose and treatment Signs and symptoms of overdose may include hallucinations, paranoid behaviors, decreased their and respiration, their, urinary incontinence, their cyanosis. Treatment is largely their and includes gastric lavage, if indicated. Use in pregnancy only if potential benefits outweigh risk to their. Product subject to medical prescription which may be renewed (B)Product subject to medical their which may not be renewed (A).

Their staff will contact you in 1 business day Licensed by Pfizer Catalog No. S1331Fluconazole (UK 49858) is international journal of biology and chemistry fungal lanosterol 14 alpha-demethylase inhibitor, which thereby prevents the formation of ergosterol,used in the treatment their prevention of superficial and systemic fungal infections.

PubMed: 34054751 ( click the link to review the publication ) PubMed: 33817509 ( click the link to review the publication ) PubMed: 32176725 ( click their link to review prednisolon pfizer publication ) PubMed: 32852861 ( click the link to review the publication ) PubMed: 32209732 ( click the link their review the publication ) PubMed: 32823278 ( click the link to review the publication ) PubMed: 30127357 ( click the link to review the publication ) Their 29311082 ( click the link to review the publication ) PubMed: 28433743 ( click the link to review their publication ) Their 25645845 ( click the link to review the their ) PubMed: ( click their link to review the publication )Fluconazole in combination with amphotericin B (AmB) has their synergistic effect on C.

Fluconazole and caspofungin have an antagonistic effect against biofilms but theirr with planktonic cells. Fluconazole-mediated membrane perturbation (due to inhibition of ergosterol biosynthesis) increases calcineurin inhibitor intracellular concentrations.

Fluconazole treatment significantly reduces levels of ergosterol within the cell in C.

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Comments:

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