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Garey et al performed a retrospective cohort study of patients with candidemia who were prescribed fluconazole at the onset of candidemia or later. After controlling for covariates, physiology plant journal one-day delay in fluconazole therapy was associated with increased total hospital costs, physiology plant journal an adequate fluconazole dose was associated with decreased total hospital costs.

Inappropriate antimicrobial therapy has been shown to be an important independent risk factor for mortality among hospitalized patients with serious infection, including bloodstream infections. Conclusion The IDSA recommends fluconazole as an option for initial therapy of presumed candidemia. Clancy's data suggest that both fluconazole MIC and dose to MIC ratio correlate with the therapeutic response to fluconazole in patients with candidemia.

Patients unable to receive high-dose fluconazole (e. Rangel-Frausto MS, Wiblin T, Blumberg HM, et al. National Epidemiology of Mycoses Survey (NEMIS): variations in rates of blood stream infections due to Candida a blood type in seven surgical intensive-care units, and six neonatal-intensive care units. McNeil MM, Nash SL, Hajjeh RA, et al.

Trends in mortality due to invasive mycotic disease in the United States, 1980-1997. Shifting patterns in the epidemiology of nosocomial Candida infections. Pittel D, Tarara D, Wenzel RP. Nosocomial bloodstream infection in critically ill patients: excess length of stay, extra costs, and attributable mortality. Wey SB, Mori M, Pfaller A, et al. The attributable mortality and excess length of stay.

Risk factors for candidal bloodstream infections in surgical intensive care unit patients: the NEMIS prospective multicenter study. Guidelines for the treatment of candidiasis. Rentz AM, Halpern MT. The impact of candidemia on length of hospital stay, outcome, and overall cost of illness. Zaoutis TE, Argon Gsk novartis, Chu J, et al.

The epidemiology and attributable outcomes of candidemia in adults and children hospitalized in the United States: a propensity analysis. Rex JH, Bennett Physiology plant journal, Sugar AM, et al. A randomized trial comparing fluconazole with amphotericin B for treatment of candidemia in patients without neutropenia. Diflucan (fluconazole) package insert. Phillips P, Shafran S, Physiology plant journal G, et al.

Multicenter randomized trial of fluconazole versus amphotericin B for treatment of candidemia in non-neutropenic patients. Eur J Clin Microbiol Infect Dis. Anaaisse EJ, Rex JH, Uzun O, et al. Predictors of adverse outcome in cancer patients with candidemia.

Nguyen MH, Peacock JE Jr, Tanner DC, et al. Therapeutic approaches in patients with candidemia: evaluation in a multicenter, prospective, observational study. Zerr DM, Garrison MM, Marr KA, et al. A meta-analysis of fluconazole versus amphotericin B for treatment of physiology plant journal Candida infections.

The National Committee for Clinical Laboratory Standards (NCCLS). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts: Approved Physiology plant journal. Rex JH, Pfaller MA.

Has antifungal susceptibility testing come of age. Rex JH, Pfaller MA, Galgiani JN, et al. Development of interpretive breakpoints for antifungal susceptibility testing conceptual framework physiology plant journal analysis of in vitro-in vivo correlation data for fluconazole, itraconazole, and Candida infections. Clancy CJ, Physiology plant journal CA, Morris A, et al.

Correlation of fluconazole MIC and response to therapy for patients with candidemia due to C. Revanker SG, Kirkpatrick WR, McAtee RK, et al. A randomized trial of continuous or intermittent therapy with fluconazole for oropharyngeal candidiasis in HIV-infected patients: clinical outcomes and development of fluconazole resistance.

Andes D, van Ogtrop M. Characterization and quantitation of the pharmacodynamics of fluconazole in a neutropenic murine disseminated candidiasis infection model. Louie A, Drusano GL, Banerjee P, et al. Pharmacodynamics of fluconazole in a murine model of systemic candidiasis. Louie A, Liu Q, Drusano GL, et al. Pharmacokinetic studies of fluconazole in rabbits characterizing doses which achieve peak levels in serum and area under the concentration time curve values which mimic those of high dose fluconazole in humans.

Rex JH, Pfaller MA, Walsh TJ, physiology plant journal al. Antifungal susceptibility testing: practical aspects and current challenges. Clancy CJ, Yu VL, Morris AJ, et al. Torres HA, Kontoyiannis DP, Rolston KV.

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