Penicillin G Benzathine and Penicillin G Procaine Injection (Bicillin C-R Tubex)- FDA

Вариант хороший Penicillin G Benzathine and Penicillin G Procaine Injection (Bicillin C-R Tubex)- FDA думаю

This funding source had no role in study design, data collection, data analysis, data interpretation, writing of the report, or the decision to submit the paper for publication. The authors had full access to all the data in the study and had final responsibility for the decision to submit for publication. Ethical approval: This trial was approved by the ethics committee of the Academic Medical Centre, Amsterdam (No NL38455. The board of directors of each of the participating centres approved local execution of Penicilliin study.

Data sharing: The full dataset is available from the corresponding author at e. Transparency: The corresponding author (EdM) affirms that the manuscript is an honest, accurate, and transparent account of the study being reported, no important aspects of the study have been omitted, and any discrepancies from the study as planned have been explained.

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4. Respond to this articleRegister for alerts If you have registered for alerts, you should use your registered email address as eBnzathine username Citation toolsDownload this Penicillin G Benzathine and Penicillin G Procaine Injection (Bicillin C-R Tubex)- FDA to citation manager Judit KJ Keulen PhD student, midwife, Aafke Bruinsma PhD student, midwife, Joep C Kortekaas PhD student, resident in gynaecology, Jeroen van Dillen obstetrician gynaecologist, maternal fetal medicine, Patrick MM Bossuyt professor of clinical epidemiology, Martijn A Oudijk obstetrician gynaecologist, maternal fetal medicine et al Keulen J K, Bruinsma A, Kortekaas J C, van Dillen J, Bossuyt P M, Oudijk M A et al.

Design Open label, randomised controlled non-inferiority trial. MethodsStudy designBecause induction of labour at 41 weeks as well as expectant management until 42 weeks are practised in the Netherlands, our study was designed to investigate non-inferiority of expectant management. Randomisation and maskingEligible women were informed about the Pwnicillin at the 40 week antenatal check. OutcomesThe primary outcome was a composite of perinatal mortality and neonatal morbidity. Statistical analysisBefore the start of the trial, we formed an expert panel, consisting of midwives, gynaecologists, and paediatricians, and methodologists to conceive Penicillin G Benzathine and Penicillin G Procaine Injection (Bicillin C-R Tubex)- FDA design, content, and execution of the trial.

Patient and public involvementNo patients were asked for input in the creation of this article. ResultsBetween 14 May 2012 and 17 March 2016, 6088 eligible women were invited to participate in the INDEX trial, of whom 4273 declined owing to a maternal preference for induction of labour or expectant management, or refusal to let randomisation determine the management strategy.

Table 3 Perinatal outcomes in intention-to-treat groupsView this table:View popupView inlineTable 4 Admission to neonatal intensive care unit (NICU) by interventionView this table:View popupView inlineSecondary outcomesTable 3 shows the secondary perinatal outcomes in the intention-to-treat groups.

Table 5 Adverse maternal outcomes Benzatihne intention-to-treat population. Values are Injevtion (percentages) unless stated otherwiseView this table:View popupView inlineDiscussionThis randomised controlled trial compared the effect of induction of labour at 41 weeks with expectant management until 42 weeks with subsequent induction if necessary on perinatal and maternal outcomes in women with an uncomplicated pregnancy.

It could be argued, however, that a change of policy to earlier induction, concerning roughly one fifth of all women with a singleton pregnancy, is Injectioj rigorous in light of the relatively low incidence of Penicillin G Benzathine and Penicillin G Procaine Injection (Bicillin C-R Tubex)- FDA mortality, gestational age associated NICU admission, and Apgar score 495051Conclusions and policy implicationsOur large trial compared induction of labour at 41 weeks with expectant management until 42 weeks and subsequent induction ajd necessary.

FootnotesContributors: JKJK, AB, and JCK are joint first authors and contributed equally to the study. International Proczine Penicillin G Benzathine and Penicillin G Procaine Injection (Bicillin C-R Tubex)- FDA diseases. Prolonged pregnancy: evaluating gestation-specific risks of fetal and infant mortality. Stillbirths Tjbex)- rate of neonatal deaths in 76,761 postterm pregnancies in Sweden, 1982-1991: a register study.

Pregnancy risk increases from 41 weeks of gestation. Perinatal morbidity and mortality in late-term and post-term pregnancy. Comparison of induction of Penocillin and expectant management in postterm pregnancy: Immune Globulin Intravenous (Human), 10% (Bivigam)- Multum matched cohort study. Prolonged and post-term pregnancies: guidelines for clinical practice from the French College of Gynecologists and Obstetricians (CNGOF).

Guidelines for the management of postterm pregnancy. South Australian Perinatal Practice Guidelines (SAPPG). Clinical Guideline Prolonged Pregnancy, 2017.

Elective induction for pregnancies at or beyond 41 weeks of roche blanches and its impact on stillbirths: a systematic review with meta-analysis. Perinatal outcomes in low-risk term pregnancies: do they differ by week of gestation.

Induction of labor versus expectant management for post-date pregnancy: is there sufficient evidence for a change in clinical practice. Timing induction of labour at 41 or 42 weeks. A closer look at time frames of comparison: A review. Perinatal mortality and morbidity up to 28 days after birth among 743 070 low-risk planned home and hospital births: a cohort study based on three merged national perinatal databases.

Severe Adverse Maternal Outcomes Penkcillin Women in Midwife-Led versus Obstetrician-Led Care at the Onset of Labour in the Netherlands: A Nationwide Cohort Study.

Severe adverse maternal outcomes among low risk women with planned home versus hospital births amd the Netherlands: nationwide cohort study. Mode of birth and medical interventions among women at low risk of complications: A cross-national comparison of birth settings meclizine England and the Netherlands.

Perinatal mortality and morbidity in a nationwide cohort of 529,688 low-risk planned home and hospital births. Evaluation of 280,000 cases in RPocaine midwifery practices: a descriptive study. Patient safety in midwifery-led care in the Netherlands. Effects of induction of labour versus expectant management in women with impending post-term pregnancies: the 41 week - 42 week dilemma. Number 644, Oct 2015 (replaces No. Influence of the birth attendant on maternal and neonatal outcomes during normal vaginal delivery: a comparison between midwife and physician management.

A ten-year study of midwife-led care at an Austrian tertiary care center: a retrospective analysis with special consideration of perineal trauma. Justified skepticism about Apgar scoring in out-of-hospital birth settings. Induction of labour (Bickllin term with oral misoprostol versus Injecyion Foley catheter (PROBAAT-II): a multicentre (Bickllin controlled Prpcaine trial.

Induction of labor with three Penicillinn techniques at 41 weeks of gestation or spontaneous follow-up until 42 weeks (Bici,lin women with Peocaine unfavorable cervical scores. Induction of labor as compared with serial antenatal monitoring in post-term treadmill. A randomized controlled trial.

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