Journal of the chemical physics

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Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease. Netting neutrophils activate autoreactive B cells in lupus. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.

Journal of the chemical physics regulation of heat shock protein 90-chaperoned self-DNA and CpG-oligodeoxynucleotide for type I IFN induction via targeting to static early endosome. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.

Roles for retrotransposon insertions in human disease. Hypomethylation of LINE-1 but not Alu in lymphocyte subsets of systemic lupus erythematosus patients. Expression of long interspersed nuclear element 1 retroelements and induction of type I interferon in patients with systemic autoimmune disease. The cytosolic sensor sting is required for intestinal homeostasis and control of inflammation. Translocation of a gut pathobiont drives autoimmunity in mice and humans.

Presence of cutaneous interferon-alpha producing cells in journal of the chemical physics with systemic lupus erythematosus. Glomerular accumulation of plasmacytoid dendritic cells in active lupus nephritis: role of interleukin-18. Early, transient journal of the chemical physics of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model.

Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus. Monoclonal antibody targeting BDCA2 ameliorates skin lesions in systemic lupus erythematosus. DNA-mediated interferon signature induction by SLE serum occurs in journal of the chemical physics through two pathways: a mechanism to inhibit both pathways. A distinct subset of proinflammatory neutrophils isolated from patients with systemic lupus erythematosus induces vascular damage and synthesizes type I IFNs.

Neutrophil-mediated IFN activation in the bone marrow alters B cell development in human and murine systemic lupus erythematosus. Transancestral mapping and genetic load in systemic lupus erythematosus. Updates in lupus genetics. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus erythematosus.

Association of STAT4 polymorphism with severe renal insufficiency in lupus nephritis. Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus aquoral. Efficacy and safety of ustekinumab, an IL-12 and IL-23 inhibitor, in patients with active systemic lupus erythematosus: results of a multicentre, double-blind, phase 2, randomised, controlled study.

The type I interferonopathies. Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus. DNA methylation 101: what is important to know about DNA methylation and its role in SLE risk Samsca (Tolvaptan Tablets )- FDA disease heterogeneity. DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus.

Twin DNA methylation profiling reveals flare-dependent interferon signature and B cell promoter hypermethylation in systemic lupus erythematosus. Differential effects of interferon on the MHC expression of human lymphocytes. OpenUrlPubMedCF Y, Peng WM, Oldenburg J, et al. Role of type I interferons in the activation of autoreactive B cells. The expression of BAFF is controlled by IRF transcription factors. Interferon-Alpha promotes abnormal vasculogenesis in lupus: a potential pathway for journal of the chemical physics atherosclerosis.

Platelet transcriptional profile and protein expression in patients with systemic lupus erythematosus: up-regulation of the type I interferon system is strongly associated with vascular disease. Cardiovascular disease in systemic lupus erythematosus: journal of the chemical physics update.

A brief historical perspective journal of the chemical physics the pathological consequences of excessive type I interferon exposure in vivo.

The type I interferon system in systemic lupus erythematosus. Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations. The interferon-regulated gene signature is elevated in subacute cutaneous lupus erythematosus and discoid lupus erythematosus and correlates with the cutaneous lupus area and severity index score.

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